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Table. Overview of efficacy of allergic rhinitis medicines for specific symptoms

Route of administration

Pharmacological class

Symptom

Itching and sneezing Rhinorrhoea Nasal congestion Ocular symptoms

Intranasal

INCS    ✔    ✔    ✔    ✔
Intranasal antihistamines    ✔      ✔    ✔
Intranasal cromolyn sodium    ✔      
Intranasal ipratropium bromide      ✔    

Oral

Oral antihistamines    ✔      *    ✔
Montelukast    *    *    *    *

Ocular

Antihistamine eye drops          ✔
Mast cell stabiliser eye drops          ✔

INCS: intranasal corticosteroids

* Small benefit demonstrated

Sources

Bousquet J, Schunemann HJ, Hellings PW et al. MACVIA clinical decision algorithm in adolescents and adults with allergic rhinitis. J Allergy Clin Immunol Pract 2016; 138: 367-74.e2. Available from: http://www.jacionline.org/article/S0091-6749(16)30148-8/pdf

Brożek JL, Bousquet J, Baena-Cagnani CE et al. Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines: 2010 revision. J Allergy Clin Immunol 2010; 126: 466-76. Available from: http://www.jacionline.org/article/S0091-6749(10)01057-2/fulltext

Hong J, Bielory B, Rosenberg JL, Bielory L. Efficacy of intranasal corticosteroids for the ocular symptoms of allergic rhinitis: A systematic review. Allergy Asthma Proc 2011; 32: 22-35. Available from: https://www.ncbi.nlm.nih.gov/pubmed/21262095

Seidman MD, Gurgel RK, Lin SY et al. Clinical practice guideline: Allergic rhinitis. Otolaryngol Head Neck Surg 2015; 152: S1-43. Abstract available from: https://www.ncbi.nlm.nih.gov/pubmed/25644617

Rodrigo GJ, Neffen H. Efficacy of fluticasone furoate nasal spray vs. placebo for the treatment of ocular and nasal symptoms of allergic rhinitis: a systematic review. Clin Exp Allergy 2011; 41: 160-70. Available from: https://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0035196

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